Breast Cancer Gene-Expression Miner v4.5
(bc-GenExMiner v4.5)
HOME
ANALYSIS
CORRELATION
Targeted
Exhaustive
Chromosomal location
EXPRESSION
Targeted
Exhaustive
Customised
PROGNOSTIC
Targeted
Exhaustive
Intrinsic molecular subtypes
Basal-like/TNBC
TUTORIAL
FLOWCHART
CORRELATION
Targeted
Exhaustive
Chromosomal location
EXPRESSION
Targeted
Exhaustive
Customised
PROGNOSTIC
Targeted
Exhaustive
Intrinsic molecular subtypes
Basal-like/TNBC
BACKGROUND
DATA CONTENT
Published annotated data
Published genomic data
Intrinsic molecular subtypes classification
DATA PRE-PROCESSING
DATA ANALYSIS
Statistical analyses
Statistical tests
Graphic illustrations
WHAT'S NEW?
HOW TO CITE US?
HOME
ANALYSIS
CORRELATION
Targeted
Exhaustive
Chromosomal location
EXPRESSION
Targeted
Exhaustive
Customised
PROGNOSTIC
Targeted
Exhaustive
Intrinsic molecular subtypes
Basal-like/TNBC
TUTORIAL
FLOWCHART
CORRELATION
Targeted
Exhaustive
Chromosomal location
EXPRESSION
Targeted
Exhaustive
Customised
PROGNOSTIC
Targeted
Exhaustive
Intrinsic molecular subtypes
Basal-like/TNBC
BACKGROUND
DATA CONTENT
Published annotated data
Published genomic data
Intrinsic molecular subtypes classification
DATA PRE-PROCESSING
DATA ANALYSIS
Statistical analyses
Statistical tests
Graphic illustrations
WHAT'S NEW?
HOW TO CITE US?
Gene correlation analysis by chromosomal location
Enter input gene:
GENE EXPRESSION DATA
First, choose your gene expression data. Information about cohorts :
microarrays
,
Affymetrix
®,
METABRIC
,
TCGA
or SCAN-B (aka GSE81540 =
GSE81538
+
GSE96058
)
Then fill the textbox with actualised* gene symbol.
*: see actualised web databases (e.g.:
GeneCards
,
Ensembl
,
HGNC
,
NCBI Gene
...)
DNA microarrays
All
(n = 10 001)
RNA-seq
All
(n = 4 712)
POPULATION
Choose one of the radio button to select which population you want to explore for patients.
RIMSPC as Robust Intrinsic Molecular Subtype Predictors Classification based on patients classified in the same molecular subtype with the six classifications. More details about molecular subtypes
here
.
All patients
Oestrogen receptor status
Progesterone receptor status
Oestrogen and progesterone receptors status combinations
Intrinsic molecular subtypes (
PAM50
)
Intrinsic molecular subtypes (
RIMSPC
)
Basal-like (PAM50) and/or TNBC (IHC)
TNBC subtypes
This analysis is only available with
Affymetrix™ data
.
This option allows you to split triple-negative breast cancer (TNBC) samples and explore their three subtypes: C1, C2 and C3:
C1
: molecular apocrine tumours (or luminal androgen receptor);
C2
: basal-like tumours infiltrated by immune suppressive cells and high neurogenesis activity;
C3
: basal-like tumours triggering an ineffective immune response; which is associated with high tumour infiltrating lymphocytes and plasma cells; tertiary lymphoid structures and upregulation of immune checkpoints.
More details about TNBC subtypes classification
here
.
Submit
Request in process...
Legend
IHC:
immunohistochemistry
PAM50:
Parker's instrinsic molecular subtypes
RIMSPC:
Robust Intrinsic Molecular Subtype Predictors Classification based on patients classified in the same molecular subtype with the six classifications.
More details about molecular subtypes
here
.
TNBC:
triple-negative breast cancer; tumours negative for oestrogen and progesterone receptors and growth factor receptor 2 (HER2), by means of IHC.
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2010
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Last update
June 22, 2020
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